A STAT1-GBP3-STING positive feedback loop governs inflammation, oxidative stress, and DNA damage to trigger acute aortic dissection [scRNA-Seq]

Acute aortic dissection (AAD) is a degenerative aortic remodeling disease characterized by exceedingly high mortality without effective pharmacologic therapies. Although oxidative stress, DNA damage, and inflammation are associated with AAD, the precise interplay among these responses has remained unclear. In this study, aortas from mouse Control and AD models were subjected to integrative ATAC-seq, RNA-seq and scRNA-seq analysis. Overall design: scRNA-seq of Control and AAD aortic tissues. ScRNA-seq was generated from from 3-4 weeks old C57BL/6 mice with ß-Aminopropionitrile drinking freely for 2 weeks and then intraperitoneal injection of angiotensin II (BAPN/AngII administration) 3 days.