mRNA profiling of Hepatocellular carcinoma (HCC). Homo sapiens

We did mRNA profiling and showed that an interferon-inducible gene's deletion and under-expression is significantly associated with shorter time to tumor recurrence, shorter progression-free survival, and shorter overall survival in HCC patients. Overall design: We got the samples from HCC patients' matched primary and recurrent tumors (n=10) and primary tumors from non-recurrent patients (n=15), we conducted the RNAseq of those samples, and did the comparison.