SEMA7A binds to integrin alpha1beta1

Sema7A has a RGD-motif in the extracellular region and interacts with alpha1beta1 integrin in both olfactory nerves and monocytes/macrophages. This interaction stimulates cytokine production in monocytes and macrophages, and is critical for the effector phase of the inflammatory immune response.

Sema7A 蛋白在细胞外区域含有RGD基序，并与嗅觉神经及单核细胞/巨噬细胞中的alpha1beta1整合素相互作用。此相互作用可刺激单核细胞和巨噬细胞产生细胞因子，对于炎症免疫反应效应阶段至关重要。