Supplementary Material for: Quality of Life after Intestinal Resection in Patients with Crohn Disease: A Systematic Review

Background/Aims: Most patients with Crohn disease (CD)
require surgery within 10 years of diagnosis. Intestinal resection is
the most commonly performed operation although the effects on
health-related quality of life (HRQOL), particularly long-term, are
contentious. Methods: We conducted a systematic review
evaluating the impact of intestinal resection on the HRQOL of CD
patients, predictors of postoperative HRQOL, and patient satisfaction
with surgery. Results: Nine studies including 1,108 CD
patients undergoing intestinal resection were identified as eligible for
inclusion. The median age at surgery was 29-41 years with varying
follow-up period (range 30 days-5 years). Ileocolic resection was the
most commonly performed operation on an elective basis (range 95-100%).
HRQOL improved as early as 2 weeks postoperatively and lasted up to 5
years across both generic and gastrointestinal domains. Gender, smoking,
and disease recurrence were potential predictors of postoperative
HRQOL. Patient satisfaction is high with regard to surgery, with
preference for a laparoscopic approach. Conclusion:
Intestinal resection in CD patients improved HRQOL in the short- and
long-term and patients describe high satisfaction about their surgery.
Further studies are needed to validate potential predictors of
postoperative HRQOL in this cohort.