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A Thrombin-PAR1/2 Feedback Loop Amplifies Thrombo-Inflammatory Endothelial Responses To The Viral RNA Analogue Poly(I:C)

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE171228
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资源简介:
This study describes a positive feedback mechanism by which thrombin sustains and amplifies the prothrombotic and proinflammatory function of endothelial cells exposed to the viral RNA analogue, poly(I:C) via activation of PAR1/2. Triplicate cultures of HUVEC were treated for 3h with poly(I:C) and/or thrombin and subjected to transcriptional profiling
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2021-04-02
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