Plasma miR-9-3p and miR-136-3p levels as novel diagnostic biomarkers for mild traumatic brain injury

Conclusions: Elevated plasma miRNA signature of miR-9a-3p, miR-136-3p and miR-434-3p distinguishes rats with mTBI from the naive, in the lateral FPI model of TBI. Further, all these miRNAs exhibit a dose-dependent increase in plasma levels with increase in injury severities.结论：在创伤性脑损伤（Traumatic Brain Injury, TBI）的侧方流体冲击损伤（Fluid Percussion Injury, FPI）模型中，血浆中miR-9a-3p、miR-136-3p与miR-434-3p的高表达特征谱，可区分轻度创伤性脑损伤（mild Traumatic Brain Injury, mTBI）模型大鼠与未造模正常大鼠。此外，上述所有微RNA（microRNA, miRNA）的血浆水平随损伤严重程度升高呈现剂量依赖性上升。