Data_Sheet_1_Type A personality, sleep quality, and cerebral small vessel disease: investigating the mediating role of sleep in a community-based study.pdf

PurposeType A behavior pattern (TABP) is a personality type characterized by rapid speech, impatience, competition, and hostility. Asymptomatic cerebral small vessel disease (CSVD) is often endemic in older adults. Individuals with TABP commonly experience suboptimal sleep quality, and a correlation exists between sleep disturbances and CSVD. We investigated the relationship between TABP and CSVD markers and further explored the mediating role of sleep quality in the relationship between TABP and CSVD.MethodsA cross-sectional survey included 764 community-dwelling adults aged 55–85 years. The TABP Scale and the Pittsburgh Sleep Quality Index (PSQI) were used to assess personality and sleep quality, respectively. Linear and logistic regression analyses were used to examine relationships between variables of interest. In addition, mediation analyses with bootstrapping were used to test whether sleep quality mediated the relationship between TABP and CSVD.ResultsOf the 764 participants [median age 65 (61–69) years, 59.9% female], the population with type A personality accounted for 44.8%. After adjusting for covariates, TABP scores (p = 0.03) and PSQI scores (p < 0.001) were significantly correlated with CSVD. In addition, sleep quality partially mediated the association between type A behavior and CSVD, and the mediating effect was 10.67%.ConclusionThis study showed that type A behavior was a risk factor for CSVD among older community-dwelling adults and that sleep quality mediated the relationship between type A behavior and CSVD. Changing type A behavior may help improve sleep quality, which may in turn reduce the prevalence of CSVD.

目的类型：行为模式A（TABP）是一种以快速言语、急躁、竞争和敌意为特征的人格类型。无症状性脑小血管病（CSVD）在老年人中常常具有地方流行性。具有TABP的个人通常睡眠质量不佳，睡眠障碍与CSVD之间存在相关性。本研究旨在探究TABP与CSVD标志物之间的关系，并进一步探讨睡眠质量在TABP与CSVD关系中的中介作用。方法：一项横断面调查纳入了764名居住在社区的55至85岁成年人。使用TABP量表和匹兹堡睡眠质量指数（PSQI）分别评估人格和睡眠质量。通过线性回归和逻辑回归分析检验了感兴趣变量之间的关系。此外，采用bootstrap方法进行中介分析，以测试睡眠质量是否在TABP与CSVD之间起中介作用。结果：在764名参与者中[中位年龄65岁（61-69岁），女性占59.9%]，A型人格人群占44.8%。调整协变量后，TABP得分（p = 0.03）和PSQI得分（p < 0.001）与CSVD显著相关。此外，睡眠质量部分中介了A型行为与CSVD之间的关联，中介效应为10.67%。结论：本研究表明，A型行为是老年人社区居住中CSVD的危险因素，且睡眠质量在A型行为与CSVD之间起中介作用。改变A型行为可能有助于改善睡眠质量，进而可能降低CSVD的发病率。