Additional file 1: Figures S1-S3. of B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis

In the baseline biopsy (A and B) Dkk-1 is not expressed in epidermis (black arrow), appendices (green arrow) and spindle-like cells (red arrows). In the follow up biopsy (C and D) there is clear expression of Dkk-1 in epidermis (black arrow), appendices (green arrow) and spindle-like cells (red arrows). All three patients responded to RTX treatment. Streptavidin biotin peroxidase (A and D × 20, B and E × 400) (ZIP 5323 kb)