Fate and Functional Roles of Prominin 1+ Cells in Liver Injury and Cancer [scRNA-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE152707
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Purpose: The goal of the study is to understand gene expression profiles of Prom1+ cells at single cell level in mouse liver cancer. Method: DEN-WAD liver from Col1a1Cre;Rosa26mTmG was perfused with collagenase. GFP+UV- cells were FACSsorted. Single cell library was constructed with 10X single gene expression v3 with 10X chromium technology. Conclusion: We identified Prom1+Afp+, Prom1+Afp-, Prom1-Afp+ gene expression profiles. These gene expression profiles revealed the markers previously observed for liver tumor intiating cells and ductular cells. In addition, they revealed novel specific markers. Single cell RNA sequencing analysis of Prom1+ cells in stellate cells depleted non-parachymal cell fraction of mouse model of liver cancer
创建时间：
2020-12-19
