Supplementary Material for: The impacts of laparoscopic restorative proctocolectomy for ulcerative colitis: Systematic review and meta-analysis

Introduction
Laparoscopic surgery (LAP) is now recognized as the standard procedure for colorectal surgery. However, the standard surgery for ulcerative colitis (UC) is total proctocolectomy with ileal-pouch anal anastomosis (IPAA), which may be an overly complex procedure to complete laparoscopically. We conducted this systematic review and meta-analysis to evaluate the efficacy as well as the advantages and disadvantages of LAP-IPAA in patients with UC stratified by the outcome of interest.
Method
We performed a systematic literature review by searching the PubMed/MEDLINE, the Cochrane Library, and the Japan Centra Reuvo Medicina databases from inception until January 2023. Meta-analyses were performed for surgical outcomes, including morbidity and surgical course, to evaluate the efficacy of LAP-IPAA.
Results
A total of 707 participants, including 341 LAP and 366 open surgery (OPEN) patients in 9 observational studies and one randomized controlled study, were included. From the results of the meta-analyses, the odds ratio (OR) of total complications in LAP was 1.12 (95% CI 0.58-2.17, p=0.74). The OR of mortality for LAP was 0.38 (95% CI 0.08-1.92, p=0.24). Although the duration of surgery was extended in LAP (mean difference (MD) 118.74 minutes (95% CI 91.67-145.81), p<0.01) and hospital stay were not shortened, duration until oral intake after surgery was shortened in LAP (MD -2.10 days (95% CI -3.52-0.68), p=0.004).
Conclusions
During IPAA for UC, a similar morbidity rate was seen for LAP and OPEN. Although LAP necessitates an extended surgery, there may be certain advantages to this procedure, including easy visibility during the surgical procedure or a shortened time to oral intake after surgery.