SWATH-MS data showing differential protein expression due to the ModS methyltransferase of Streptococcus suis

Streptococcus suis is a significant cause of bacterial meningitis in humans, particularly in S.E. Asia, and is a leading cause of respiratory and invasive disease in pigs. Phase-variable DNA methyltransferases, associated with Restriction-Modification (R-M) systems, are a source of epigenetic gene regulation, controlling the expression of multiple genes throughout the genome. These systems are known as phasevarions (phase-variable regulons), and have been characterised in many host-adapted bacterial pathogens. We recently established the presence of a Type III DNA methyltransferase in S. suis (ModS), of which two alleles were described, ModS1 and ModS2. Strains which expressed either ModS1 or ModS2 exhibited differential methylation throughout the genome when compared with strains which did not. This altered methylation resulted in changes to gene expression and this SWATH-MS dataset demonstrates the resulting changes to protein expression as a result of the of ModS1 and ModS2. This dataset represents triplicate repeats from strains which express ModS (ON) and strains which do not (OFF).