Knowledge-based grouping of canonical pathways that were significantly enriched for CAD genetic loci.

The enrichment score was defined as the mean of negative log-transformed Kolmogorov-Smirnov and Fisher P-values for over-representation of high-ranking GWAS SNPs among the eSNPs that affect the expression of the pathway member genes. The number in parentheses in the first column indicates the number of CAD-associated pathways (detailed in Table S1). *FDR<20% in Stage 1 and 2 respectively, and FDR<5% in combined Stage 1 & 2.