Association of PTM-type and PIN-property specific protein sets with known human disease proteins.

Protein sets were sorted in descending order of the respective PIN-property and the top/bottom 25% tested for overlap with human disease genes reported in OMIM (http://www.ncbi.nlm.nih.gov/omim) based on a Fisher’s exact test with FDR-correction with respective counts of proteins binned according to binary decisions top/bottom 25% property and disease association yes/no forming the 2×2 contingency table. p-values highlighted red indicate significant overlap of the top-25% set of proteins for a particular network property with human disease proteins, while blue values signify larger than expected overlaps of the bottom-25% protein sets with proteins annotated to be involved in disease processes at p-value thresholds of p-value 0.05, 0.01 (if underlined), respectively. Black font color indicates no significant overlap of neither the top nor the bottom 25% set.Association of PTM-type and PIN-property specific protein sets with known human disease proteins.