THE IMPACT OF CHRONIC STRESS ON THE PATHOPHYSIOLOGY AND CLINICAL COURSE OF HEART FAILURE

This study is aimed at a complex analysis of the role of chronic stress in the development and course of heart failure (HF). The problem is that in modern medicine, the direct effect of chronic stress on HF has not been sufficiently studied, and mechanisms for its prevention or management have not been fully implemented in clinical practice. The objective of the research is to identify the main mechanisms affecting the pathophysiology of HF under chronic stress and to evaluate its impact on clinical results. As a methodology, analysis of modern literature, systematization of clinical research results, and generalization of statistical data were used. The main result is that chronic stress accelerates the development of HF and worsens its course through activation of the hypothalamic-pituitary-adrenal axis (HPA axis), increased inflammatory processes, and hyperactivity of the sympathetic nervous system. In conclusion, the management of chronic stress should be an important part of HF prevention and treatment strategies.