Crescentic GN_repository.xlsx

This was an observational retrospective cohort study done in outpatient and inpatient services of the Department of Nephrology in our hospital. We included all patients (≥18 years) who underwent native renal biopsy at our centre between January 2006 to December 2015 and had ≥50% crescents on histology. Data on their demographic profile, clinical features, biochemical parameters, histopathology, treatments, morbidity and mortality were retrieved from the electronic patient records (Clinical WorkStation) maintained in the hospital. Follow-up clinical and outcome data with regards to their serum creatinine, dialysis requirement, and complications were collected for each review visit till August 2016. During the index and follow up visits, patients were classified into chronic kidney disease (CKD) stages as per estimated glomerular filtration rate (eGFR) calculated by CKD-EPI equation. Crescentic glomerulonephritis (Cr.GN) was defined as the presence of ≥50% glomerular crescents as the principal histologic finding. Patients were categorized into three groups on the basis of etiology of crescentic GN- anti-GBM crescentic GN (type I Cr.GN), immune complex crescentic GN (type II Cr.GN), pauci-immune crescentic GN (type III Cr.GN). Approval was obtained from the Institutional Review Board (Silver, Research and Ethics Committee) of the Christian Medical College, Vellore, India (IRB 9090 dated 06.10.2014). As this was a retrospective cohort and had de-identified patient data retrieved from electronic records, the Ethics committee has given waiver of consent.