Genome-wide DNA methylation analysis of driver genes in blood of high-altitude pulmonary edema

High Altitude Pulmonary Edema (HAPE) is a disease that interacts with environmental and epigenetic factors with a severe clinical course and high mortality rate. This study aims to investigate DNA methylation alterations of HAPE and identify the driver genes. The Illumina Infinium MethylationEPIC BeadChip (850K) was used to obtain DNA methylation profiles across 860,000 CpGs in blood of 6 HApe patients and 6 healthy volunteers. We identified differentially expressed of DNA methylation regions and CpG sites in a discovery set (6 HAPE patients and 6 healthy controls) using 850k high-throughput sequencing.All of the participants and health care volunteers were Han Chinese people between the ages of 18 and 65 who had travelled to Tibet.