IL37 binds IL18R1

Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1F7) is a member of the IL-1 family. There are five isoforms of IL37 (a e) of which transcript IL-37 is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. Like several other IL-1 family members, IL-37 is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function. (Kumar et al. 2002). Both full length and processed IL-37 can bind the Interleukin 18 receptor 1 (IL-18R1) but binding of processed IL-37 is more effective (Shi et al. 2003, Kumar et al. 2002). Subsequently, Single Ig IL-1 related receptor (SIGIRR, TIR 8,IL-1R8) is recruited and facilitates the suppression of cytokine production in several types of immune cells resulting in reduced inflammation.

白细胞介素（IL）是一类免疫调节蛋白，能够在细胞和组织中激发多种反应。白细胞介素37（IL-37，IL-1F7）是IL-1家族的成员。IL37（a至e）存在五种同源异构体，其中转录本IL-37已知具有功能（Sharma等，2008年）。该同源异构体在UniProt中被表征为IL-37的典型形式，在Reactome中被表征为IL-37的全长、未加工形式。与IL-1家族的多个成员类似，IL-37以前体形式合成，需要经过处理（主要由caspase 1处理）才能获得完整的受体激动剂或拮抗剂功能。（Kumar等，2002年）。全长和加工过的IL-37均能结合白细胞介素18受体1（IL-18R1），但加工过的IL-37的结合效果更为显著（Shi等，2003年，Kumar等，2002年）。随后，单链IgG IL-1相关受体（SIGIRR，TIR 8，IL-1R8）被招募，并促进多种免疫细胞中细胞因子生产的抑制，从而导致炎症减轻。