A Dieckmann Cyclization Route to Piperazine-2,5-diones
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/A_Dieckmann_Cyclization_Route_to_Piperazine_2_5_diones/2517871
下载链接
链接失效反馈官方服务：
资源简介：
Piperazine-2,5-diones are formed by Dieckmann cyclization
(NaH,
THF) of substructures of the type CH2-N(R)C(O)CH2N(R′)CO2Ph in which
the terminal methylene (CH2)
that is adjacent to nitrogen closes onto the carbonyl group of the
phenyl carbamate unit at the other end of the chain. R and R′
are alkyl groups, and the terminal methylene is activated by a ketone
carbonyl, a nitrile, an ester, or a phosphoryl group. The starting
materials are assembled by standard acylation and oxidation processes,
starting from a β-(alkylamino)alcohol, an (alkylamino)acetonitrile,
an (alkylamino) ester, or an (alkylamino)methyl phosphonate.
创建时间：
2016-02-20
