Analysis of functional roles of Regnase-1 in airway epithelial cells controlling mucosal immunity

Regnase-1 is an RNase critical for the regulation of immune cell activation. In addition to hematopoietic cells, we found that Regnase-1 is expressed in the airway epithelial cells. Mice lacking Regnase-1 specifically in airway epithelial cells showed the enhanced induction of immune reaction in response to Pseudomonas aeruginosa infection. Thus, we performed transcriptome analysis using wild-type and Regnase-1-deficient MTECs (mouse tracheal epithelial cells) to analyze the underlying mechanism of Regnase-1 mediated regulation of airway epithelial cell activation.