Epigenomic Profiling of Human B Cell Subsets. Epigenomic Profiling of Human B Cell Subsets

Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-mapping algorithm to identify candidate causal variants for 21 autoimmune diseases from genotyping data. We integrated these predictions with transcription and cis-regulatory element annotations, derived by mapping RNA and chromatin in primary immune cells, including resting and stimulated CD4(+) T-cell subsets, regulatory T cells, CD8(+) T cells, B cells, and monocytes. This study includes human B cell ChIP-Seq data included in the following publication: Farh, Kyle Kai-How, et. al PMID 25363779.