Dihydrocoumarin, an extract of Melilotus officinalis, inhibits IgE-dependent mast cell activation in vitro and in vivo

In summary, dihydrocoumarin could suppress MC activation in vitro and in vivo through inhibiting the MAPKs and NF-kB pathways.综上所述，二氢香豆素（dihydrocoumarin）可通过抑制丝裂原活化蛋白激酶（MAPKs）与核因子-κB（NF-κB）信号通路，在体外及体内环境中抑制肥大细胞（MC）的活化。