Data from: Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest

The incidence of post-cardiac arrest myocardial dysfunction (PAMD) is
high, and there is currently no effective treatment available. This study
aims to investigate the protective effects of exogenous mitochondrial
transplantation. Exogenous mitochondrial transplantation can enhance
myocardial function and improve the survival rate. Mechanistic studies
suggest that mitochondrial transplantation can limit impairment in
mitochondrial morphology, augment the activity of mitochondrial complexes
II and IV, and raise ATP level. As well, mitochondrial therapy ameliorated
oxidative stress imbalance, reduced myocardial injury, and thus improved
PAMD after cardiopulmonary resuscitation (CPR). Our study aims to
investigate the protective effects of exogenous mitochondrial
transplantation on the myocardium following cardiac arrest. We utilize a
rat model of asphyxiation-induced cardiac arrest. Once the model is
established, the rats are humanely euthanized for sample collection or
survival analysis.