Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TK-453
收藏Protein Data Bank Japan2023-11-29 更新2026-03-28 收录
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https://pdbj.org/mine/summary/7vxg
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Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TK-453 Descriptor: 6-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-3-[2,3-bis(chloranyl)phenyl]sulfanyl-pyrazin-2-amine, Tyrosine-protein phosphatase non-receptor type 11 Authors: Li, T.H, Guo, H.T, Ji, X.Y. Deposit date: 2021-11-12 Release date: 2022-03-23 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis. Iscience, 25, 2022
创建时间：
2021-11-12
