Activity-induced Regulation of Synaptic Strength through the Chromatin Reader, L3mbtl1. Mao et al.

L3mbtl1 is an activity dependent chromatin reader protein that regulates homeostatic down-scaling. • Ctnnb1 is one of the target genes of L3mbtl1 that mediates synaptic homeostasis. Our results highlight a critical role for the activity-regulated chromatin reader molecule in homeostatic control of synaptic strength and adds to our understanding of epigenetic mechanisms of activity-dependent gene regulation.