Characteristics of TP53 mutants found and clinical data

°, Nucleotide number; 1, The bolded bases indicate the base change; 2, Functional predictions derived from a computer model that takes into account the 3D structure of wild-type and mutant proteins and is trained on the trans activation dataset from Kato et al. Mutations are classified as “functional” or “non-functional”. More details here: http://www-p53.iarc.fr/Help.html#StructureClass; a, Frequencies reported in IARC database (http://www.iarc.fr/p53/) release October 2006. The frequencies are based on a total of 22822 reported mutations in all type of cancer and in 2274 reported mutations in breast cancer (brackets); T N M, TNM-classification, AJCC 2002 = UICC 2002, T, size or direct of the primary tumor; N, spread to regional lymph nodes; M, distant metastasis; ˆ, “F” followed by a number indicates that the patient was free of disease at that number of months of follow-up. “R” followed by a number indicates that the patient was alive at that number of months of follow-up but had suffered a relapse; ®, Site of relapse L, Locoregional; S, Skeletal; V; Visceral; *, “A” followed by a number indicates that the patient was alive at that number of months of follow-up. “D” followed by a number indicates that the patient died at that number of months of follow-up; ‡, Characterized as a mutation affecting L2/L3 domain, since it leads to truncation of the protein and will mostly affect L2/L3 domain; AI, Allelic imbalance; NA, Not available; ND, not done; NI, Not informative.