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Photoredox-Catalyzed Cascade Radical Cyclization of Ester Arylpropiolates with CF<sub>3</sub>SO<sub>2</sub>Cl To Construct 3‑Trifluoromethyl Coumarin Derivatives

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NIAID Data Ecosystem2026-03-10 收录
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We report a highly efficient method to construct 3-trifluoromethyl coumarins using CF3SO2Cl as the trifluoromethyl radical source with ester 3-arylpropiolates. The reaction incorporated a cascade cyclization/dearomatization/ester migration/oxidization/rearomatization process to afford various 3-trifluoromethyl coumarins under visible light irradiation in good to excellent yields.

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2018-06-19
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