Proteomics of Staphylococcus aureus

Tannic acid (TA) and punicalagin(P), which both are polyphenols, have attracted much attention in recent years due to its extensive physiological activities, which include antioxidant, antitumoral, antimicrobial and anti-inflammatory actions. Previous work revealed that TA has an inhibitory effect on a variety of bacteria, including S. aureus, Salmonella, and Lactobacillus. Previous researches suggested that TA inhibited bacterial growth by chelating ions from the culture medium, and by inhibiting fatty acid synthesis through suppression of the activity of β-ketoacyl-ACP reductase, or by interfering with cell wall integrity. However, the mechanisms underlying the inhibitory effect of TA and P on S.aureus have not been assessed comprehensively. Therefore, the present study combined transcriptome and proteome data to analyze the molecular mechanisms of TA and P in S. aureus.