Lung expression data from young and old mice at ZT0 and ZT12. Lung expression data from young and old mice at ZT0 and ZT12

Circadian rhythms control the diurnal nature of many physiological, metabolic and immune processes. Circadian rhythms are tighly controlled by positive and negative transcriptional loops; This circuitry is altered during aging altering tissue daily function. We used microarrays to detail the global programme of gene expression underlying age-mediated alteration of the transcriptional progarm in lungs. Overall design: Lungs from 2-month-old and 18-month-old male mice were harvested at ZT0 (light on) and ZT12 (light off). RNA were then extracted and hybridised on a Affymetrix microarrays.