Pseudomonas aeruginosa PA14 Transcriptome or Gene expression

P. aeruginosa is a versatile pathogen capable of causing a wide variety of infections. Patients with thermal (burn) injuries are very susceptible to P. aeruginosa infections. These infections often spread from the wound site and become systemic. P. aeruginosa virulence has been extensively studied, however, most studies utilize synthetic growth media which is tailored to optimize the expression of certain virulence factors. In this study, we compared the gene expression of P. aeruginosa PA14 grown in blood from several healthy volunteers versus blood obtained from patients with severe thermal (burn) injuries. We observed several distinct trends in gene expression from P. aeruginosa grown in blood obtained from burn patients when compared to expression in healthy volunteers.