Hip1 complex with inhibitor #1 (Hip1-1) via Ser228

Hip1 complex with inhibitor #1 (Hip1-1) via Ser228 Descriptor: N-(dihydroxymethyl)-L-phenylalanyl-N-[(2R,3S)-2-hydroxy-1-methoxy-5-methyl-1-oxohexan-3-yl]-L-lysinamide, Protease Authors: Yim, M.K, Olsen, K.J, Brooks, C.L, Pena, K.J, Johnson, S.J, Goldfarb, N.E. Deposit date: 2024-12-05 Release date: 2025-12-17 Last modified: 2026-04-15 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Discovery of highly potent alpha-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis. Eur J Med Chem Rep, 15, 2025