Uncarialines A-E, new alkaloids from Uncaria rhynchophylla and their anticoagulant activity
收藏科学数据银行2023-04-27 更新2026-04-23 收录
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资源简介：
Uncarialines A-E (1-5), five undescribed monoterpene indole alkaloids, together with five known analogues were obtained from the stems of Uncaria rhynchophylla. Alkaloids 1-3 were unique 3,4-seco-tricyclic alkaloids with a 6/5/10 ring system, while 4 and 5 possessed a rare rearranged scaffold originated from corynantheine-type alkaloids with C-2/C-7 oxidation. Their structures were characterized by a comprehensive analysis of MS, NMR, and ECD. Their effects on blood clotting times of human plasma were evaluated and alkaloid 5 had a slight prolongation effect on both thrombin time and activated partial thromboplastin time (p < 0.001).
提供机构：
Kunming Institute of Botany, Chinese Academy of Sciences
创建时间：
2023-03-31
