Holstein Friesian signature matrix for cell type deconvolution of blood

These files are additional data from the paper 'Profiling the immune epigenome across global cattle breeds' (https://doi.org/10.1186/s13059-023-02964-3). HF_SignatureMatrix_Heatmap.pdf: heatmap showing the methylation levels of the CpG sites across the cell types used to build the Holstein Friesian signature matrix. HF_SignatureMatrix_CpGsites_PercentMeth.txt: list of CpG sites included in the Holstein Friesian signature matrix (1-based coordinates) generated using CIBERSORTx with their percentage methylation across all samples studied. The sample ID indicates the breed (HF denotes Holstein Friesian and ND denotes N'Dama), ENA animal ID (for the corresponding animal ID used in the original manuscript see Additional file 3: Table S10), and cell type (Bcell = B cell, CD4 = CD4 T cell, CD8 = CD8 T cell, gdT = γδ T cell, NK = NK cell, mono = monocyte and gran = granulocyte). CibersortInput_HF_PercentMeth_Reference.txt: The reference sample file uploaded to Cibersortx to generate the Holstein Friesian signature matrix. CibersortInput_Phenotypes.txt: The phenotype classes file uploaded to Cibersortx to define the Holstein Friesian reference sample file.