MYC-deficiency impairs the development of effector/memory T lymphocytes. MYC-deficiency impairs the development of effector/memory T lymphocytes

Using scRNA-seq we investigate the impact of the absence of MYC on physio-pathological development of PTEN-proficient or PTEN-deficient T lymphocytes. We demonstrate that MYC-deficient effector/memory T cells is drastically reduced. MYC is then essential for effector/memory differentiation Overall design: Single cell RNA-seq study of T lymphocyte differentiation in Pten and/or Myc deleted mice