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Inflammatory signals from fatty bone marrow support DNMT3a-driven clonal hematopoiesis (NOD/SCID/IL-2Rgc-null subset)

ChEBI2023-02-19 更新2026-07-12 收录

克隆性造血机制

免疫缺陷小鼠模型

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-12620 数据链接链接失效反馈

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资源简介：

Inflammatory signals from fatty bone marrow support DNMT3a-driven clonal hematopoiesis (NOD/SCID/IL-2Rgc-null subset)

应用场景：

创建时间：

2023-02-19

消化道微生物组

免疫缺陷小鼠模型

Superscript letters across rows denote significant difference at P<0.05 determined using Mann Whitney U test. “Unclassified” are taxa in the families listed that are yet to be classified with a genus

NIAID Data Ecosystem80

Oncostatin M is a Master Regulator of an Inflammatory Network in Dnmt3a-Mutant Hematopoietic Stem Cells

干细胞转录组学

克隆性造血机制

Age-associated clonal hematopoiesis (CH) occurs due to somatic mutations accrued in hematopoietic stem cells (HSCs) that confer a selective advantage in the context of aging. The mechanisms by which C

NIAID Data Ecosystem40

TET2 Deficiency Increases the Competitive Advantage of Hematopoietic Stem Cells through Upregulation of Thrombopoietin Receptor Signaling

克隆性造血机制

表观遗传靶向治疗

Ten-Eleven Translocation-2 (TET2) mutations drive the expansion of mutant hematopoietic stem cells (HSCs) in clonal hematopoiesis (CH). However, the precise mechanisms by which TET2 mutations confer a

NIAID Data Ecosystem30

Bladder weights and inhibitory rates observed in 4 BALB/c-nu mice (%).

临床前药效评估

免疫缺陷小鼠模型

(Compared with the normal saline group: **P<0.01) Bladder weights and inhibitory rates observed in 4 BALB/c-nu mice (%).

NIAID Data Ecosystem80

Inflammatory signals from fatty bone marrow support DNMT3a-driven clonal hematopoiesis (Dnmt3A KI heterozygote subset)

克隆性造血机制

白血病早期演化

Accumulation of fatty bone marrow (FBM) is one of the key age related changes possibly influencing the blood system. While a link between obesity and cancer evolution has been reported it remains unkn

NIAID Data Ecosystem30

Inflammatory signals from fatty bone marrow support DNMT3a-driven clonal hematopoiesis (NOD/SCID/IL-2Rgc-null subset)

资源简介：

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