WP399 - Wnt signaling and pluripotency - Homo sapiens

This pathway was adapted from several resources and is designed to provide a theoretical framework to examine Wnt signaling and interacting components in the context of embryonic stem-cell pluripotency and self-renewal.
A central organizing theme of this pathway is known drug targets that promote self-renewal or pluripotency (BIO and IQ-1)
and implicated upstream regulators of the core pluripotency transcriptional components (e.g. Nanog). It is unclear whether all the depicted components participate in this pathway in human embryonic stem cells.
Interactions and object/gene groups for the pathway exist for the majority of components.

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP399).