Overview of evolutionary conserved regulators across three organisms.

Conserved regulators between E. coli, B. subtilis, and S. enterica and the corresponding number of the modules which are enriched as the targets of these regulators. The same module numbers are used as in Table S2. Targets' co-expression conservation: refers to whether the known targets of the corresponding regulator showed co-expression conservation across the studies species (i.e. they were detected on the core part of the co-expressed module). Regulator co-expression conservation: refers to whether the corresponding regulator itself showed co-.expression conservation across the studied species. The non-orthologous regulators between E. coli and B. subtilis predicted as being functional counterparts i.e. they are responsible for co-expression conserved target genes are highlighted by bold characters.