Decoupling Lineage-Associated Genes in Acute Myeloid Leukemia Reveals Inflammatory and Metabolic Signatures Associated with Outcomes

AML is a heterogeneous disease with current genomic and cytogenetic based classifications do not fully account for patient-to-patient variability. By decoupling lineage-related changes from transcriptomic signatures and integrating orthogonal genomic and proteomic based assays, we uncovered AML group of patients with inflammatory and metabolic signatures that inform outcomes. Assessment of newly diagnosed AML patients