16S rRNA sequencing and Targeted Metabolomics Analyses Reveal Rhizosphere Microbial Diversity and Flavonoids Dynamics in Scutellaria baicalensis Georgi

Scutellaria baicalensis Georgi is a commonly used bulk Chinese medicinal material in China. Clinically, it is often divided into Ziqin and Kuqin respectively into medicine, and herbal research and pharmacological studies have shown that Ziqin and Kuqin have different effects. Therefore, we collected the S. baicalensis and its rhizosphere soil at different growth periods to explore the influence of soil microorganisms on drug synthesis.This study showed that soil physicochemical properties and soil microorganisms would affect the accumulation of flavonoids in S. baicalensis , which provided an important basis for improving the quality of S. baicalensis through reasonable fertilization and precise microbiota management.