Pathway analysis for aging-related genes.

Lists of significantly (p≤0.05, two-way ANOVA main effect of age) down- and up-regulated genes were subjected to overrepresentation analysis using DAVID's clustering function (Methods). Representative pathways from each cluster found to have significantly more genes than expected by chance (p≤0.05, modified Fisher's exact test) are shown. The pathway (bold) is followed in parentheses by the number of genes found to be significant in that pathway (#) and the likelihood that such a number could be found by chance (p = ). This is followed by a list of the gene symbols within that pathway.