KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine

KIAA1456 (TRM9L, hTRM9L) transfers a methyl group from S-adenosylmethionine (AdoMet) to 5-carboxymethyluridine in tRNA, yielding 5-methoxycarbonylmethyluridine (5-(2-methoxy-2-oxoethyl)uridine) (Begley et al. 2013). The subcellular location of the reaction is unknown.

KIAA1456（TRM9L，hTRM9L）将甲基团从S-腺苷甲硫氨酸（AdoMet）转移至tRNA中的5-羧甲基尿苷，生成5-甲氧基甲酰甲基尿苷（5-（2-甲氧基-2-氧乙基）尿苷）（Begley等，2013年）。该反应的亚细胞定位尚不明确。