NHLBI TOPMed - NHGRI CCDG: The GENetics in Atrial Fibrillation (GENAF) Study

The Genetics in AF (GENAF) study enrolled individuals with early-onset lone AF before age 50 in Norway between 2009 and 2016. Early-onset was defined as diagnosis of AF before age 50. Lone AF was defined as AF in the absence of clinical or echocardiographic findings of cardiovascular disease, hypertension, metabolic or pulmonary disease. AF was documented in ECG. All participants underwent clinical examination, including ECG, echocardiography, and blood draw, from which DNA has been extracted. The study conforms to the principles of the Declaration of Helsinki and was approved by the Regional Ethics Committee (REK) in Norway (Protocol reference number: 2009/2224-5). All included patients gave written informed consent.]]>
TOPMed Whole Genome Sequencing Methods: Freeze 9TOPMed Whole Genome Sequencing Methods: Freeze 10Inclusion Criteria Age ≥ 18 years Competency to consent Signed written, informed consent Atrial fibrillation documented in ECG (Atrial fibrillation of at least 30 seconds duration in ECG- or Holter- recording) before age 50 years Exclusion Criteria AF secondary to cardiac or pulmonary disorder, such as: Hypertension Heart failure Coronary heart disease COPD Pulmonary embolism Congenital structural heart disease AF secondary to other conditions, such as: Hyperthyroidism Infectious conditions Alcohol- or drug abuse Other conditions which make a genetic cause of the arrhythmia unlikely, based on the investigators judgement. ]]>