Hmga2

Enables minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including negative regulation of cellular senescence; positive regulation of angiogenesis; and positive regulation of cell proliferation in bone marrow. Acts upstream of or within several processes, including endocrine system development; lung development; and positive regulation of cell population proliferation. Located in male germ cell nucleus and nuclear chromosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2). [provided by Alliance of Genome Resources, Nov 2024]

该数据集激活富含腺嘌呤-胸腺嘧啶的DNA的微小沟结合活性。参与多个过程，包括细胞衰老的负向调控；血管生成的正向调控；以及骨髓中细胞增殖的正向调控。在包括内分泌系统发育、肺发育以及细胞群体增殖正向调控等过程中发挥上游作用或存在于其中。定位于男性生殖细胞核及其核染色体。在多个结构中表达，包括消化系统、大脑、泌尿生殖系统、长骨肢体和感觉器官。该基因的人类同源基因与银-拉塞尔综合征、平滑肌瘤、脂肪瘤和卵巢癌有关。与人类HMGA2（高移动性组AT钩2）同源。[由基因组资源联盟提供，2024年11月]