Expression data from SUN2 downstream

SAD1/UNC84 domain protein-2(SUN2) is a member of the inner nuclear membrane LINC (linker of nucleoskeleton and cytoskeleton) complex, which maintains nuclear structure by connecting the nuclear lamina to the cytoskeleton. SUN2 is located at the inner nuclear membrane, where it extends into the perinuclear space via its C-terminal SUN domain and interacting with the nuclear lamina through its nucleoplasmic N-terminal domain. SUN2 might serve as a potential therapeutic target in cancer . Hsieh TH et al. showed that SUN2 inhibits cell proliferation and tumor malignancy both in vitro and in vivo and plays a tumor suppressor gene in central nervous system embryonal tumors. SUN2 are decreased in breast tumor tissues compared with mammary epithelial tissues. Our group has previously reported that SUN2 suppresses the Warburg effect by repressing the expression of GLUT1 and LDAH in lung cancer cells. These data suggest that the function of SUN2 is different in various cancers. However, the role of SUN2 in colon cancer remains unclear.In this study, we used the microarray to indentify the dnownstream of SUN2 in HCT116 after knocking down SUN2. scr and shSUN2-1 were for RNA extraction and hybridization on Affymetrix microarrays.