crystal structue of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor
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crystal structue of Thrombin in complex with a potent P1 heterocycle-Aryl based inhibitor Descriptor: (2-[6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-YL)ETHYL]AMINO}-2-OXOPYRAZIN-1(2H)-YL]-N-[5-CHLORO-2-(1H-TETRAZOL-1-YL)BENZYL]ACETAMIDE, Hirudin, thrombin Authors: Young, M.B, Barrow, J.C, Glass, K.L, Lundell, G.F, Newton, C.L, Pellicore, J.M, Rittle, K.E, Selnick, H.G, Stauffer, K.J, Vacca, J.P, Williams, P.D, Bohn, D, Clayton, F.C, Cook, J.J, Krueger, J.A, Kuo, L.C, Lewis, S.D, Lucas, B.J, McMasters, D.R, Miller-Stein, C, Pietrak, B.L. Deposit date: 2004-03-05 Release date: 2004-08-03 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors J.Med.Chem., 47, 2004
创建时间：
2004-03-05
