Data Base - Association of NER SNPs with Parkinson’s Disease Risk A Case–Control Study in a Mexican Mestizo Population

This case–control study investigated the association between genetic variants in the nucleotide excision repair (NER) pathway and susceptibility to Parkinson’s disease (PD) in a northern Mexican mestizo population, with attention to gene–environment interactions. The study included 137 PD patients and 137 age- and sex-matched healthy controls. Clinical evaluation covered motor and non-motor symptoms, cognitive function, depression, and environmental exposures (notably pesticides). Serum biochemical markers were measured, and genotyping for ERCC1 (rs11615), ERCC2 (rs13181), XPA (rs1800975), XPC (rs2228001), and XPF (rs1799801) was performed using TaqMan real-time PCR assays.Results showed a higher prevalence of pesticide exposure among PD cases (OR 2.08, p = 0.01), especially in men. Only XPC rs2228001 was significantly associated with PD: the C/C genotype increased risk (OR 2.27, p = 0.03), with a stronger effect in men under a recessive model (OR 3.16, p = 0.029) after adjusting for pesticide exposure. Male PD patients also had lower serum uric acid levels (p = 0.001), suggesting reduced antioxidant capacity. No associations were found for the other SNPs or for ERCC1–ERCC2 haplotypes.These findings suggest that impaired DNA repair due to the XPC rs2228001 variant, particularly in men with pesticide exposure, may contribute to PD risk. The results highlight the importance of integrating genetic and environmental factors into PD pathogenesis models and call for replication in larger, multiethnic cohorts with functional validation.