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Striatal genes regulated by super-enhancers and displaying low paused RNAPII are preferentially down-regulated in Huntington's disease

ChEBI2015-04-01 更新2026-07-21 收录

神经退行性分子机制

表观遗传与转录调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-59572 数据链接链接失效反馈

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Striatal genes regulated by super-enhancers and displaying low paused RNAPII are preferentially down-regulated in Huntington's disease

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创建时间：

2015-04-01

神经退行性分子机制

TDP-43蛋白功能

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear TDP-43. Here we identify that TDP-43 regulates expression of the neuronal growth-associated fa

NIAID Data Ecosystem130

Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease

神经退行性分子机制

毒蕈碱型乙酰胆碱受体药理

Cholinergic transmission at muscarinic acetylcholine receptors (mAChR) has been implicated in higher brain functions such as learning and memory, and loss of synapses may contribute to the symptoms of

PubMed Central1996-11-26 更新50

Additional file 2 of The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

神经退行性分子机制

脑老化脂质稳态

Supplementary Material 2

DataCite Commons2023-11-21 更新40

Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by extracellular alpha-synuclein

α-突触核蛋白毒性

神经退行性分子机制

MES cells were treated with vehicle or 250 nM extracellular alpha-synuclein and plasma membrane proteins were labeled with biotin, followed by affinity purification. The biotinylated enriched membrano

NIAID Data Ecosystem60

Additional file 1 of Integrated identification of key genes and pathways in Alzheimerâs disease via comprehensive bioinformatical analyses

阿尔茨海默病生物标志物

神经退行性分子机制

Table S1. Information for samples in the included datasets. (ArrayExpress datasets). Included detailed information of samples of hippocampus and entorhinal cortex regions extracted from GSE48350. (XLS

Figshare2019-07-16 更新40

Striatal genes regulated by super-enhancers and displaying low paused RNAPII are preferentially down-regulated in Huntington's disease

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