small RNA seq profile of DG and CA region of mice subjected to 2 or 10 weeks of environmental enrichment and their respective home cage controls. Mus musculus

Physical exercise in combination with cognitive training is known to improve memory function and lower the risk for various complex diseases including Alzheimer’s disease. Here we show that prolonged exposure of mice to such an environmental enrichment paradigm mediates long-lasting beneficial effects on memory function and synaptic plasticity even after the end of enrichment training and also provides a cognitive advantage to the offspring. We furthermore show that this effect is mediated via changes in sperm RNA involving the expression of miR-212/132. Overall design: small RNA profile from adult animals (hippocampal DG or CA region) subjected to 2 weeks or 10 weeks of enrvironmental enrichment