Relative activity of the studied single and double promoters in different cell lines.

The values represent relative promoter activities as ratios of the luciferase activity expressed by plasmids containing promoters under study to the luciferase activity expressed by a pGL3-PV plasmid containing only the SV40 promoter. Mean values (± SEM) of relative luciferase activity were calculated from three independent experiments.
Sign “+” in the first column means that data are calculated as an arithmetic sum of activities of single constituent promoters. The average value of promoter activity over five cancer cell lines (Calu-1, A375, A549, PANC-1, and HT1080) was calculated as a sum of the activities in each line divided by 5. The rightmost column corresponds to normal lung fibroblasts IVL-11NS.