cholesterol + PAPS => cholesterol sulfate + PAP

The 3-hydroxyl groups of a number of sterols can undergo sulfonation. Cholesterol sulfate is particularly abundant in the body, and may have both regulatory and biosynthetic functions (Strott and Higashi 2003). Its synthesis is catalyzed by the b isoform of SULT2B1 (Fuda et al. 2002; Javitt et al. 2001).

众多甾醇的3-羟基基团可发生磺化反应。胆固醇硫酸酯在人体内含量尤为丰富，可能兼具调控与生物合成功能（Strott 和 Higashi 2003）。其合成过程由SULT2B1的β型异构体催化（Fuda 等人 2002；Javitt 等人 2001）。