Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors
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Substituted Pyrazoles as Hepatselective HMG-COA reductase inhibitors Descriptor: (3R,5R)-7-[1-(4-fluorophenyl)-4-(1-methylethyl)-3-{methyl[(1R)-1-phenylethyl]carbamoyl}-1H-pyrazol-5-yl]-3,5-dihydroxyheptanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION Authors: Pavlovsky, A, Pfefferkorn, J.A, Harris, M.S, Finzel, B.C. Deposit date: 2007-08-31 Release date: 2008-04-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. J.Med.Chem., 51, 2008
创建时间：
2007-08-31
